Tricks and tricorders: the automation of primary care

The Tricorder X-Prize is an international innovation challenge promising $US10 million to a team that can crack the elegantly elusive problem of the 'tricorder', the legendary handheld health analyser originally featured in Star Trek that has the 'tri-functionality' of sensing, computing and recording health.

A little black box with a screen and detachable probe, the tricorder could sense vital signs, analyse blood work and diagnose a range of medical conditions. Although it was able to send distress signals, the tricorder could not deliver treatment; it was a portable, easy-to-use diagnostic toolkit.

Almost 50 years after this device appeared on television screens, the med-tech community has seized upon it as a legitimate scientific goal. The $10m Tricorder X-Prize was announced in 2011 and seven teams are now in the running, with the winner to be announced in early 2017.

The criteria for the device have been laid down: it must be able to diagnose the following 10 so-called 'core conditions': anaemia, UTI, diabetes, atrial fibrillation, obstructive sleep apnoea, COPD, pneumonia, otitis media and leukocytosis.

The 10th core condition – the absence of the other nine – is perhaps the most treacherous of them all if you read the fine print in the prize guidelines. The gold standard that devices are held against to prove this null hypothesis is a very thorough work-up indeed: test subjects undergo bloods, ECG, CXR, lung function tests, sleep apnoea tests and a brain MRI.

This list is actually a less ambitious version of what was proposed in 2011 when the prize first launched. There were originally three further conditions required: hepatitis A, tuberculosis and stroke. For bonus points, there is also an extra set of 12 'elective conditions' to grapple with including pertussis, hyperthyroidism and HIV.

Devices must also be able to record five vital signs (blood pressure, heart rate and variability, temperature, respiratory rate and oxygen saturations), with a push towards continuous monitoring and upload to cloud storage.

In the running

The seven teams that remain in the running include four from the US and one each from Taiwan, Canada and India. The Canadian team CloudDx has put forward the Vitaliti platform (pictured), an app-based analytics tool that syncs with multiple sensors including a wireless otoscope and a microphone for analysing breath sounds. Vitaliti also has a range of test cassettes for samples of finger-prick blood, urine and saliva.

Scanadu, based out of the NASA Ames Research Center in Silicon Valley, has already gone to market with an early prototype, the Scanadu Scout, which will detect vital signs and provide basic recommendations for $US199. The company is now developing more sophisticated consumer health trackers called Scanadu Vitals and Scanadu Urine, and it already publishes large-scale deidentified data through its Global Body Map, foreshadowing the potential for real-time population analytics of health metrics.

Then there is Boston's DNA Medicine Institute (DMI) team, supported by the National Institutes for Health and the Bill and Melinda Gates Foundation. DMI recently took out the smaller Nokia Sensing X Prize with its Reusable Handheld Electrolyte and Lab Technology for Humans (rHEALTH) device, a miniaturised pathology lab able to perform 22 tests on a single drop of blood using microfluidics and laser spectrometry.

Victory will be in the detail, but the skeleton of these ideas has already been sketched out. All of them involve a range of wireless sensing devices for vital signs and laboratory testing, linked to a software platform that recognises trends and provides a diagnostic prediction.

Future practice

As these teams converge on a solution, the question we have to grapple with is this: how would a tricorder-style diagnostic device actually work in the delivery of healthcare? After all, it only solves one half of the equation: it identifies a problem, but can't initiate treatment.

One could argue that if you have diagnosed a UTI, taking the next step and suggesting appropriate antibiotic therapy for an uncomplicated patient is not a huge technical leap. However, patients are rarely uncomplicated, and even if there are no objective medical complications, the psychosocial intricacies of healthcare mean that general practice and sensor technology will have to work hand in hand.

This may not be such an odd coupling as some people, who prophesy the end of traditional primary care with technological innovation, would have us believe. On the contrary, sensing technology might actually be the most useful tool for GPs in bringing efficiency to an increasingly overburdened primary healthcare system.

Let's consider the most frequent presentations to a GP clinic. Cooke et al. analysed almost 200,000 Australian patient encounters from 2009-2010 using data from the BEACH program to produce a list of the problems most frequency managed by general practitioners.

Numbers one to 10 were:

  • Hypertension
  • Immunisations/vaccinations
  • Acute upper respiratory tract infections
  • Depression
  • Diabetes
  • Lipid disorders
  • General check-ups
  • Osteoarthritis
  • Back pain
  • Prescription refilling.

This list is notably different from the Tricorder Prize's top-10 list of acute conditions. The only item on this list that would typically require a tricorder-style spot diagnosis would be acute upper respiratory tract infection.

Apart from URTIs, almost all the other presentations relate to management of chronic conditions, perhaps with the exception of immunisations and general check-ups. So the question of automating primary care is really one of automating chronic disease management. This is where user-driven health tracking stands to be extremely useful.

Imagine if ...

Imagine if the GP's decision about anti-hypertensive medications was informed by an accurate day-by-day trace of a patient's blood pressure over the last month, along with medication compliance, exercise levels and heart rate. We then move from trial-and-error medicine to tailored therapy.

Imagine if the management of diabetes was informed by detailed BSL tracking, HbA1c levels and urine dipstick tests performed in a patient's home.

Imagine if analgesia for chronic back pain was titrated in real time based on pain scores and side effect profile, just as it is for hospital inpatients.

Imagine if cholesterol checks could be done in the household and subjects triaged to physicians accordingly. Primary care would be all the richer for it.

At a minimum, these sensing platforms could make primary care decision-making asynchronous: rather than a patient physically attending the GP, browsing through tattered copies of Women's Weekly in the waiting room, sitting face-to-face and leaving with some advice, that same advice could be delivered electronically via a GP who reviews the health data at a time that suits them.

However, we can go one step further. The picture that is really taking shape is of an automated concierge for chronic disease management in the home, advising on medications and lifestyle modifications in real time between visits to the GP. Of the 10 most common GP-managed problems, almost all could be tracked in a semi-automated fashion with the kind of devices competing for the Tricorder Prize.

Primary care should not see these technologies as a rival, but as an ally. We are now at a critical fork in the road where we can build an ecosystem (including the regulatory and billing structures) to cater for semi-automated community medicine, and where private enterprises will be vying to get the automation right.

As members of the medical profession, we should embrace these technologies and make them work for us, integrate them into our practice and let them extend our capacities, rather than fear them as robotic competitors.

Martin Seneviratne is a junior medical officer at the Royal Prince Alfred Hospital in Sydney.

Posted in Australian eHealth

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